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Types of disease
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Sepsis
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Pneumonia
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Urinary tract infections (UTI)
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Infective agents
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Escherichia coli
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Klebsiella pnaumoniae
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Pseudomonas aeruginosa
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Staphylococcus aureus
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Streptococcus pneumoniae
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Oncology models
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Xenografts of human cancer cells in nude mice
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Allografts of mouse cancer cells in immunocompetent mice
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Applications:
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Subcutaneous tumors
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Orthotopic tumor
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Efficacy of a drug in a mouse model of disease
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Different routes of administration (intravenous, intraperitoneal, intratracheal/pulmonary, intraurethral
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Pharmacokinetics
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Area under the Drug Concentration Curve (AUC<)
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Volume of Distribution (Vd)
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Clearance
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Toxicity
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no observed adverse effect level (NOAEL)
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maximum tolerated dose (MTD)
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Integrated optical and microCT technology
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3D optical tomography for fluorescence and bioluminescence
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Cerenkov imaging for optical radiotracer imaging
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DyCE™ dynamic enhanced imaging for real time distribution studies of both fluorochromes or PET tracers ideal for PK/PD applications
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microCT, low dose and ultra fast
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Applications:
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Infectious diseases
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Oncology
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Musculo-skeletal research
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Cardiovascular research
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Neurology research
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Respiratory research
